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September 26, 2025International Journal of BioprintingOpen Access

3D bioprinting of a perfusable tumor microenvironment model to investigate perfusion and chemotherapeutic responses in ovarian cancer cells

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Authors

MSMd ShahriarMMMarielena MolinaresGAGanesh Acharya

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Overview

This study demonstrates perfusion impacts on chemotherapeutic response in SKOV3 ovarian cancer cells, indicating the model's relevance for tumor microenvironment research.

Key Points

  • SKOV3 ovarian cancer cells showed increased viability of 96% near the perfusion channel at 300 μm distance.
  • Carboplatin exposure reduced cell viability to 5% at 50 μM, demonstrating a dose-dependent response.
  • Extrusion- and inkjet-based bioprinting was used to create a perfusable GelMA-gelatin-based tumor model.
  • This model highlights the importance of perfusion in evaluating drug responses and tumor heterogeneity.

Cite This Study

Shahriar et al. (2025) studied this question.

synapsesocial.com/papers/68d6cd63b1249cec298b361ahttps://doi.org/10.36922/ijb025320316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 13D Bioprinting of High-Grade Serous Ovarian Cancer Cells: Workflow for Gelatin-Based Bioink Formulation with Hyaluronic Acid and Printability Assessment2026
  2. 2Abstract 4860: Predicting therapy efficacy and revealing tumor heterogeneity using patient-derived 3D bioprinted ovarian cancer models2026
  3. 3Abstract 4048: 3D bioprinted cancer models for drug screening versus 2D and <i>in vivo</i> models: A comparison study2026
  4. 4Generation of mixed ovarian cancer and fibroblast spheroids by bioprinting2026
  5. 5Pneumatic extrusion bioprinting-based high throughput fabrication of a melanoma 3D cell culture model for anti-cancer drug screening2024 · 14 citations