Objectives To investigate the association between serum uric acid (UA) and high-risk plaques (HRPs) assessed by coronary CT angiography (CCTA). Methods In this retrospective study, we included outpatients who underwent CCTA. HRP was defined as ≥any 2 of the following features: positive remodelling, low-attenuation plaque (LAP), napkin ring sign and spotty calcification. Plaque volume, Agatston score, vessel stenosis, segment stenosis score (SSS) and segment involvement score (SIS) were also determined by CCTA. Logistic regression analysis was used to assess the relationship between serum UA and the risk of HRP. Receiver operating characteristic (ROC) curve analysis was performed to assess model’s accuracy and discrimination. Subgroup analysis based on sex (male/female), diabetes mellitus (yes/no), smoking status (yes/no), alcohol use (yes/no), obstructive coronary artery disease (CAD) (yes/no), Agatston score (0.05). Conclusion Serum UA is an independent risk factor for high-risk coronary artery plaques on CCTA. Measuring serum UA might provide improvement of discrimination and reclassification for CAD when added to clinical characteristics.
Long et al. (Tue,) studied this question.
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