Evaluation of Ozonized Fibrin-Rich Plasma as a Therapy for Facial Rejuvenation: A Case Report Series

INTRODUCTION: Facial rejuvenation through ozonized injectable platelet-rich fibrin (I-PRF) represents an innovative approach that combines regenerative and bio-oxidative properties. OBJECTIVES: To report and describe the outcomes of five patients treated with ozonized injectable platelet-rich fibrin (I-PRF). CASE REPORT: Five patients (four women, one man; age range: 25-70 years) presented with complaints of skin laxity, uneven texture, hyperpigmentation, expression lines, or scars. No participants had systemic contraindications to treatment. The therapeutic protocol involved three monthly sessions of ozonized I-PRF injections in multiple facial areas (glabella, periorbital region, nasolabial fold, and chin). At the 60-day follow-up after the final session, patients demonstrated visible improvements in skin quality, with a reduction of expression lines, increased elasticity, enhanced muscle tone, and decreased pigmentation. No adverse effects or complications were observed. CONCLUSION: This case report series suggests that the combination of autologous fibrin matrices with ozone may enhance regenerative outcomes, offering a promising alternative in aesthetic practice.