A Novel Treatment Schedule Combining Injectable Platelet‐Rich Fibrin and Endolift Laser for Facial Rejuvenation: A Case Report

The combination of Endolift laser therapy and injectable platelet‐rich fibrin (i‐PRF) is an emerging strategy in aesthetic medicine, but the optimal scheduling of these modalities remains unexplored. This case report highlights a novel treatment schedule combining i‐PRF and Endolift laser therapy, resulting in noticeable short‐term facial rejuvenation in a 56‐year‐old female. A 56‐year‐old woman presented with concerns regarding facial skin laxity and aging. A unique treatment schedule was implemented: i‐PRF injections were administered 1 day before (Day −1), 1 week after (Day +7), and 1 month after (Day +30) a single Endolift laser session (Day 0). At the 4‐week follow‐up, the patient demonstrated marked improvement in skin tightness, texture, and overall facial appearance, as assessed by clinical examination, standardized photography, and high patient‐reported satisfaction. Only mild, transient adverse effects were observed, with no delayed complications. This novel schedule combining i‐PRF and the Endolift laser demonstrates promising synergistic effects, resulting in significant short‐term skin rejuvenation. While these initial findings suggest that the precise timing of i‐PRF enhances the regenerative impact of Endolift therapy, further large‐scale studies utilizing objective measurement scales and extended follow‐up periods (3–6 months) are warranted to validate long‐term durability and establish standardized protocols.