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September 23, 2025Synfacts

Synthesis of Benzo[b]azepin-2-ones from 1,7-Dienes and TBPB-Mediated Oxidation of Alcohols

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Key Points

Benzo[b]azepin-2-ones were successfully synthesized through oxidative cyclization, showcasing a novel methodology for this compound.
The process utilized α-oxyalkyl and acyl radicals to promote the reaction, enhancing the efficiency of the synthesis.
Oxidative cyclization was applied using TBPB for oxidation, significantly improving reaction conditions and yields.
These findings suggest potential applications in developing new compounds in medicinal chemistry.

Implication

Synthesis demonstrates production of benzo[b]azepin-2-ones from 1,7-dienes, indicating new pathways in radical chemistry.

Abstract

Keywords benzo[b]azepin-2-ones - oxidative cyclization - α-oxyalkyl radicals - acyl radicals - 1,7-dienes

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Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68d6d82e8b2b6861e4c3e0bb https://doi.org/10.1055/a-2680-8521

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