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September 24, 2025Clinical Kidney JournalOpen Access

Comparison of radioactive and non-radioactive iothalamate and hippuran to assess kidney function

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The cold method shows equivalent mGFR results compared to the warm method, reducing radioactive exposure.
Accuracy was impressive with 100% of the warm and cold mGFR measurements within ±30%, and 76% within ±10%.
Methods used included gamma counting for the warm method and LC-MS/MS for the cold method, assessing 220 participants.
The study highlights the cold method's precision while the warm method faced bias due to radiochemical impurities.

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Comparison of radioactive and non-radioactive iothalamate and hippuran to evaluate kidney function.

Mohamed et al. (2025) studied this question.

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