Why the study?
Does nonradioactive iohexol clearance accurately measure GFR compared to 125I-iothalamate clearance in adults?
Population
41 adults, 54% males, mean age 50.7 years, with varying degrees of renal impairment.
Comparison
Nonradioactive iohexol clearance method… vs 125I-iothalamate clearance method.
Design
Cross-sectional
Authors
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Supports nonradioactive iohexol for GFR estimation; leaves open prospective validation before clinical adoption.
Does nonradioactive iohexol clearance accurately measure GFR compared to 125I-iothalamate clearance in adults?
Nonradioactive iohexol clearance using a modified monoexponential model provides a simple and accurate method for determining GFR across varying degrees of renal impairment.
Rocco et al. (1996) studied this question.
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