What question did this study set out to answer?

The aim is to evaluate iohexol plasma clearance as a reliable method for assessing renal function in transplant settings.

Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting

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Randomized trial demonstrates pragmatic iohexol GFR determination in renal transplantation, indicating enhanced accuracy over traditional methods.

The aim is to evaluate iohexol plasma clearance as a reliable method for assessing renal function in transplant settings.
Developed a population pharmacokinetic model for iohexol clearance.
Evaluated limited sampling schedules using 1 to 4 blood draws after iohexol administration.
Performed internal and external validation with diverse renal transplant recipients.
Achieved a mean relative prediction error < ± 0.5% and P10 > 97% for optimal sampling schedules.
Three to four blood draws within 3 hours produced a mean absolute relative prediction error < 5.5% and P10 ≥ 85%.
Proposed tools can accurately evaluate GFR in clinical situations lacking conventional accuracy.

Zwart et al. (2021) studied this question.

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Randomized trial demonstrates pragmatic iohexol GFR determination in renal transplantation, indicating enhanced accuracy over traditional methods.