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September 24, 2025Journal of PerinatologyOpen Access

Prophylactic surfactant therapy in the era of less invasive surfactant delivery

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Authors

DKDinushan C. KaluarachchiAKAnup KatheriaPPPatrick Peebles

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Overview

Review discusses efficacy of prophylactic surfactant for preterm infants, suggesting safer delivery methods.

Key Points

  • Prophylactic surfactant administration via thin catheter appears safe and effective.
  • Recent findings indicate that invasive ventilation is minimized with less-invasive surfactant delivery methods.
  • Ongoing randomized clinical trials are evaluating thin catheter surfactant administration in preterm infants.
  • Surfactant delivery via supraglottic airway and aerosolization requires further investigation.

Cite This Study

Kaluarachchi et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8768b2b6861e4c3ea87https://doi.org/10.1038/s41372-025-02420-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Very Early Surfactant Without Mandatory Ventilation in Premature Infants Treated With Early Continuous Positive Airway Pressure: A Randomized, Controlled Trial2008 · 230 citations
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  3. 3A randomised controlled trial in preterm infants comparing prophylactic with selective “less invasive surfactant administration” (pro.LISA)2023 · 9 citations
  4. 4Aerosolized Calfactant for Newborns With Respiratory Distress: A Randomized Trial2020 · 94 citations
  5. 5European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update2023 · 715 citations