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September 24, 2025Open Access

Acute Promyelocytic Leukemia: Pathophysiology, Diagnosis and Clinical Management

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Comprehensive review highlights APL pathophysiology and coagulopathy, emphasizing timely diagnosis and therapy.

Acute promyelocytic leukemia is highly treatable with timely diagnosis, and early intervention is crucial.
The PML-RARα oncoprotein impairs differentiation and promotes leukemic cell survival through retinoic acid signaling disruption.
Diagnosis combines cytomorphology, immunophenotyping, coagulation studies, and molecular confirmation for accuracy.
All-trans-retinoic acid treatment, along with aggressive supportive care, is essential for managing APL-associated coagulopathy.

Abddaoui et al. (2025) studied this question.

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