Synthesis of Functionalized Cyclic Ethers via Gold‐Catalyzed Cyclization and Rearrangement

Cyclic ethers are prevalent structural motifs in natural products and pharmaceuticals, and their efficient synthesis has attracted significant attention in organic synthesis. A synthetic approach for the functionalization of cyclic ethers from ortho ‐alkynylarylmethanol derivatives protected by cyclic ethers via gold‐catalyzed intramolecular cyclization and rearrangement is developed. The gold‐catalyzed 6‐ endo ‐dig cyclization yielded various functionalized cyclic ethers. Furthermore, this transformation enabled the synthesis of C ‐glycoside derivatives from alkynyl compounds bearing O ‐glycosides.