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This is a Literature Review study.

Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy

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This review reveals metabolic dysfunction's role in cognitive decline in Alzheimer's disease, suggesting targeted therapies may improve outcomes.

Targeting metabolic pathways may slow cognitive decline in Alzheimer's disease, offering novel therapeutic strategies.
Key disruptions like insulin resistance and mitochondrial inefficiency influence neuronal energy deficits and synaptic dysfunction.
Therapeutic approaches include insulin sensitizers, ketogenic diets, and mitochondrial antioxidants shown in early studies.
Addressing both metabolic dysfunction and neuroinflammation could enhance treatment efficacy in Alzheimer's disease.

Barnwal et al. (2025) studied this question.

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This review reveals metabolic dysfunction's role in cognitive decline in Alzheimer's disease, suggesting targeted therapies may improve outcomes.