Study of Serum Creatinine Level in Essential Hypertension: An Observational Study

A BSTRACT Introduction: Hypertension—a major global health concern affecting over 1.13 billion individuals—is a key contributor to cardiovascular, cerebrovascular, and renal diseases. Materials and Methods: A cross-sectional study was conducted at P.R. Pote Hospital, Amravati, including 70 hypertensive patients and 50 normotensive controls aged 30–50 years. After a 12-hour fast, blood samples were collected, and serum creatinine levels were estimated using a semi-auto analyzer. Statistical analysis involved t-tests, Mann–Whitney U tests, and correlation studies. Results: Hypertensive patients had significantly higher mean serum creatinine levels (0.88 mg/dL) than normotensive individuals (0.77 mg/dL). Serum creatinine positively correlated with both systolic and diastolic blood pressure. Moderate positive correlations were also observed with cholesterol, LDL, and VLDL, while HDL showed a weak negative correlation. Discussion: These findings indicate a clear association between hypertension and renal function decline. The correlations with lipid profiles further support existing evidence of metabolic involvement. Conclusion: Regular monitoring of serum creatinine in hypertensive patients is crucial for early detection of renal impairment and prevention of chronic kidney disease progression.