Advances in Continuous‐Flow Synthesis of Nitrogen‐Containing Heterocycles Through Sequence Transformations in the Past Decade (2016–2025)

Nitrogen‐containing heterocycles are widely distributed in realm of natural products, pharmaceuticals, and function materials. Compared to the traditional batch synthesis, continuous‐flow technology emerges as a transformative platform with multiple advantages, such as enhanced mass/heat transfer, precise temperature control, continuous large‐scale production, minimizing the need for intermediate separation and purification, and safe operation etc. Based on the continuous‐flow strategies, this review systematically evaluates recent advances for the synthesis of nitrogen‐containing heterocycles through sequence transformations in the past decade (2016–2025), including three‐, four‐, five‐, six‐, seven‐membered ring. Furthermore, in combination with heterogeneous catalysis, photocatalysis, electrocatalysis, or microwave radiation etc., the continuous‐flow technology greatly enriches the organic synthesis pathways and produces diversified nitrogen‐containing heterocycles and related pharmaceuticals.