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September 27, 2025JAMA Network OpenOpen Access

Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care

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Authors

WLWiep R. De LignyJBJan Peter de BruinRSRoos M. Smits

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Overview

Randomized clinical trial shows no improvement in ongoing pregnancy rates for men with antioxidant supplements, indicating potential treatment reconsideration.

Key Points

  • Ongoing pregnancy rates did not improve significantly with antioxidant supplementation compared to placebo, highlighting treatment limitations.
  • Adjusted odds ratio indicated a lower ongoing pregnancy rate in the antioxidant group within an optimal treatment window, suggesting ineffective intervention timing.
  • The randomized clinical trial design included 1171 men across various fertility clinics, providing comprehensive insights into the efficacy of antioxidants.
  • These findings may lead to a rethink of antioxidant use in fertility treatments for men, given the absence of improvement in major outcomes.

Cite This Study

Ligny et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc52367e8https://doi.org/10.1001/jamanetworkopen.2025.32405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1(616) Effect of Multicomponent Antioxidant Therapy on Semen Parameters and Pregnancy Outcomes in Infertile Men2026
  2. 2P-093 The effect of antioxidant supplementation on sperm quality in infertile men: a randomized placebo-controlled clinical trial2024
  3. 3OXIDATIVE STRESS AND MALE FERTILITY: THE IMPACT OF ANTIOXIDANT BLENDS IN TREATMENT2026
  4. 4The Effect of Oral Antioxidant Supplementation on Infertile Male, Infertile Obese Male, Intracytoplasmic Sperm Injection (ICSI) Outcome and Pregnancy Rate2024
  5. 5Micronutrient Antioxidants for Men (Menevit®) Improve Sperm Function by Reducing Oxidative Stress, Resulting in Improved Assisted Reproductive Technology Outcomes2024 · 9 citations