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September 27, 2025LifeOpen Access

The Gut Microbiota–Sex–Immunity Axis in Non-Communicable Diseases

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Authors

MCMario CaldarelliPRPierluigi RioLFLaura Franza

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Overview

Observational studies reveal sex differences impacting gut microbiota and immune responses in NCDs, suggesting new preventive strategies.

Key Points

  • Gut microbiota contributes to immune regulation and metabolic homeostasis in non-communicable diseases.
  • Studies indicate that biological sex affects gut microbiota composition, which influences disease predisposition.
  • Unique metabolites from gut microbiota, like short-chain fatty acids, have sex-specific effects on inflammation and immunity.
  • Future research should focus on longitudinal, sex-stratified studies to better understand gut microbiota roles in health.

Cite This Study

Caldarelli et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc5236947https://doi.org/10.3390/life15101510
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