Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 20, 2025Clinical Microbiology Reviews

The sex hormone-gut microbiome axis: mechanistic drivers of sex-disparate bacterial infection outcomes and precision clinical interventions

View Full Paper
Ask AI
Bookmark
Share

Authors

LTLi TangPXPeilu XieHWHao Wang

Discussion

Loading...

Member takes

Overview

This review uncovers the role of the gut microbiome in bacterial infections, suggesting implications for sex-specific probiotics and clinical interventions.

Key Points

  • Investigate the mechanistic drivers behind sex differences in bacterial infection outcomes and potential clinical interventions.
  • Reviewing epidemiological and preclinical data related to sex disparities in bacterial infections.
  • Analyzing the role of sex hormones and gut microbiome interactions in immunity and infection.
  • Highlighting targeted therapies such as hormone-modulated probiotics and fecal microbiota transplantation.
  • Identified sex-specific differences in susceptibility to infections like Helicobacter pylori and Listeria monocytogenes.
  • Demonstrated the gut microbiome's role in modulating immune responses and infection severity.
  • Proposed precision interventions, including microbiome diagnostics and targeted therapies to optimize infection management.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc350178https://doi.org/10.1128/cmr.00236-25
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Gut Microbiota–Sex–Immunity Axis in Non-Communicable Diseases2025 · 5 citations
  2. 2Microecological modulators—new perspectives for treating sex hormone disorders2026
  3. 3How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection2026 · 1 citations
  4. 4Sex and regional effects of Bacteroides in the gut2025 · 2 citations
  5. 5Sex and regional effects of <i>Bacteroides</i> in the gut2026