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September 27, 2025Microbiology and Molecular Biology Reviews

Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets

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Authors

BCByron CaugheyEAEfrosini ArtikisDSDaniel Shoup

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Overview

Review examines prions and protein aggregates as biomarkers and therapeutic targets, highlighting structural biology and diagnostics.

Key Points

  • Prions and protein aggregates are linked to several neurodegenerative diseases, causing significant health issues.
  • The formation of amyloid fibrils, which are crucial in disease advancement, shows strain-like conformers across different diseases.
  • Mechanisms such as seeded polymerization support the development of sensitive assays for diagnostics, aiding clinical assessments.
  • Understanding the structures and spreading mechanisms of pathogenic aggregates may lead to innovative therapeutic strategies.

Cite This Study

Caughey et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3e2eebfec0fc5236a37https://doi.org/10.1128/mmbr.00007-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond prion‐like spreading in neurodegenerative disease2025 · 2 citations
  2. 2Recent Advances in Mapping Protein Self-Assembly and Aggregation for Common Proteinopathies2024 · 1 citations
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  4. 4The structural line between prion and “prion-like”: Insights from prion protein and tau2024 · 5 citations
  5. 5Genetic Modulators of Prion-Like Protein Propagation in Alzheimer's Disease2024 · 1 citations