This article discusses treatment options for resistant hypertension, suggesting next steps in pharmacologic management.
Resistant hypertension (RH) is defined as blood pressure (BP) that remains above goal despite treatment with three first-line pharmacologic classes or BP that requires four or more medications to obtain control. After ruling out secondary causes and implementing nonpharmacologic treatments, clinicians may encounter the question of which pharmacologic treatment options should be used next. This article discusses evidence-based second-line medication options for RH.
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Walter et al. (2025) studied this question.
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