Why the study?
Resistant hypertension currently extends beyond its classical definition, warranting a review of its clinical relevance, associated high-risk phenotypes, and current or future treatments.
This review provides an overview of the clinical relevance, phenotypes, and therapeutic strategies for resistant hypertension.
Refines resistant hypertension phenotypes for clinical recognition; extends definitions while leaving optimal strategies open.
Resistant hypertension (RH) is a concept that currently goes beyond the classical definition of blood pressure ≥140/90 mmHg in subjects receiving three or more drugs of different classes at maximally tolerated doses. Here, we review the clinical relevance of RH and the different types of RH-associated phenotypes, namely refractory hypertension, controlled resistant hypertension, and masked uncontrolled hypertension. We also discuss current drug strategies and future treatments for these high-risk phenotypes.
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Ruilope et al. (2019) studied this question.
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