This mechanochemical method demonstrates high yields of N-substituted phthalamides, suggesting a novel reaction pathway in organic synthesis.
The transamidation (aminolysis) of phthalimide with primary and secondary aliphatic amines is reported, where reactivity is induced by mechanical forces without the need for catalysts, acids, or thermal activation. The reaction proceeds at room temperature to afford N-substituted phthalamides as the major products. It is carried out in a mixer mill using stainless-steel jars and balls. The scope is demonstrated with more than 20 examples, achieving yields of up to 98%.
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Morales-Manrique et al. (2025) studied this question.
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