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September 27, 2025Chemical Communications

Rh(III)-Catalyzed Cyclization of 5-Amino-pyrazoles with Maleimides to Pyrazoloquinazolines

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The new method yields functionalized pyrazolo[1,5-a]quinazoline derivatives efficiently.
Cycloaddition of 5-amino-1-aryl-pyrazoles and maleimides shows promise for diverse applications.
This is a one-step synthesis that simplifies the production of spirocyclic compounds.
Rh(III) catalyst enhances reactivity, reducing time and effort in the synthesis process.

Implication

Novel Rh(III) protocol synthesizes spirocyclic pyrazoloquinazolines from pyrazoles and maleimides, indicating ease of functionalization.

Abstract

We report a novel Rh(III)-catalyzed [5 + 1] cycloaddition protocol for the one-step synthesis of functionalized spirocyclic pyrazolo[1,5-a]quinazoline derivatives (PZQZLs, 3) from 5-amino-1-aryl-pyrazoles (1) and maleimides. This method exploits the...

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Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc5237619 https://doi.org/10.1039/d5cc04547a

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Implication

Novel Rh(III) protocol synthesizes spirocyclic pyrazoloquinazolines from pyrazoles and maleimides, indicating ease of functionalization.

Rh(III)-Catalyzed Cyclization of 5-Amino-pyrazoles with Maleimides to Pyrazoloquinazolines

Key Points

Implication

Abstract

Discussion

Cite This Study

Rh(III)-Catalyzed Cyclization of 5-Amino-pyrazoles with Maleimides to Pyrazoloquinazolines

Key Points

Implication

Abstract

Discussion

Cite This Study

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