Effectiveness of a Multi-Interventional Package on Quality of Life among Chronic Kidney Disease Patients Receiving Hemodialysis

Introduction: chronic kidney disease (CKD) patients undergoing Hemodialysis often experience reduced Health-Related Quality of Life (HRQoL) due to complications such as depression, malnutrition, and physical limitations. Despite the burden, studies examining HRQoL interventions in India remain scarce. Objectives:This study aimed to (1) assess HRQoL among CKD patients before and after a multi-interventional package, (2) evaluate its effectiveness compared to routine care, and (3) explore associations between HRQoL and demographic variables. Methods: A quasi-experimental pretest–posttest control group design was conducted among 240 CKD patients on Hemodialysis (120 experimental, 120 control) selected by purposive sampling. HRQoL was assessed using the KDQoL-SF-36 scale. The experimental group received an eight-week multi-interventional package including structured exercise, nutritional supplementation (Neels Nephro Mix), guided imagery, and Benson’s relaxation technique, while the control group received routine care. Results: The majority of participants were aged 46–55 years, with an equal gender distribution and diabetes as the most common comorbidity. Pretest HRQoL scores were poor across groups. After intervention, 97.5% of the experimental group improved to average/good HRQoL, showing a 34% increase in scores, compared to a 16% improvement in controls. Significant improvements were noted in physical, mental, and ESRD-specific domains (p < 0.05). Occupation and education were significantly associated with post-test HRQoL. Conclusion: The multi-interventional package significantly improved HRQoL among CKD patients on Hemodialysis. Integrating exercise, nutrition, and relaxation strategies with routine care is recommended to enhance patient outcomes and reduce complications.