Efficacy of Nurse Driven Interventional Package on Quality of Life and Biochemical Markers Among Patient With Ckd”-a Pilot Randomized Controlled Study

Objectives: Chronic kidney disease (CKD) negatively affects quality of life (QoL) and biochemical stability. This pilot randomized controlled trial evaluated the effectiveness of a nurse-led intervention (nutrition counseling, chair-based exercises, mindfulness) on QoL and biochemical parameters among CKD patients. Methods: A pretest–posttest randomized controlled design was conducted in a tertiary nephrology unit. Twenty participants were randomized equally to intervention (n=10) or control (n=10). The intervention lasted 4 weeks. Outcomes included QoL (KDQOL-36) and biochemical parameters (serum creatinine, hemoglobin, GFR). Statistical analyses included paired t-tests and effect sizes. Ethical approval and trial registration were obtained. Results: The intervention group showed significant improvement in QoL (t(4)=8.92, p<0.001, Cohen’s d=1.94). Biochemical trends were favorable, with reduced creatinine and improved GFR, though not statistically significant. Conclusions: A nurse-led holistic package improved QoL and suggested stabilization of biochemical parameters. This intervention is feasible and warrants testing in larger RCTs.