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This is a Quantitative Study study.

NCBI Orthologs: Public Resource and Scalable Method for Computing High-Precision Orthologs Across Eukaryotic Genomes

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Resource reveals high-precision orthologs across eukaryotic genomes, suggesting advancements in comparative genomics.

This resource provides high-precision ortholog assignments, vital for studying eukaryotic gene evolution.
By integrating protein similarity and nucleotide alignment, the system achieves scalable orthology inference across diverse eukaryotes.
The methodology employs a decision tree to ensure high-confidence one-to-one orthology relationships among genomes.
Access to ortholog data is facilitated via the NCBI Gene and Datasets resources, enabling broader functional annotation efforts.

Oh et al. (2025) studied this question.

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