What question did this study set out to answer?

To expand evolutionary and functional orthology annotations across an extensive sampling of species and enhance tools for comparative genomics and assembly quality assessment.

November 13, 2024Nucleic Acids ResearchOpen Access

OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes

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To expand evolutionary and functional orthology annotations across an extensive sampling of species and enhance tools for comparative genomics and assembly quality assessment.
Delineated hierarchical orthologous groups across eukaryotic, prokaryotic, and viral lineages using the OrthoLoger pipeline.
Integrated coding DNA sequences, gene loci coordinates, and programmatic interfaces via REST API, SPARQL/RDF, Python, and R Bioconductor.
Packaged the OrthoLoger inference tool and ODB-mapper component using Conda and BioContainers to streamline annotation of newly sequenced genomes.
Expanded OrthoDB content to encompass 5,827 eukaryotic genomes annotated with evolutionary and functional descriptors.
Updated BUSCO benchmarking sets to provide standardized quality assessments across eukaryotic and prokaryotic assemblies, transcriptomes, and metagenomic bins.
Released ODB-mapper to automate the functional mapping of novel genomic sequences to existing orthologous groups.

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Implication

Database update reports expanded ortholog annotations across 5,827 eukaryotic genomes, facilitating functional genomics and assembly benchmarking.

Cite This Study

Tegenfeldt et al. (2024) studied this question.

synapsesocial.com/papers/69df126f5fcfdd3525591937 https://doi.org/10.1093/nar/gkae987

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Implication

Database update reports expanded ortholog annotations across 5,827 eukaryotic genomes, facilitating functional genomics and assembly benchmarking.

OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes

Key Points

Discussion

Implication

Cite This Study

OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes

Key Points

Discussion

Implication

Cite This Study

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