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September 27, 2025Cancer ControlOpen Access

Is Site of Radiation Therapy Associated With Pathologic Complete Response in Patients With Locally Advanced Esophageal Cancer?

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No significant difference in pathologic complete response rates was found between high-volume centers and community centers.
SCC histology showed higher pCR rates at high-volume centers compared to community centers, though not statistically significant.
Most patients had adenocarcinoma, with neoadjuvant chemoradiation delivered at community centers more frequently.
The rate of ypN0 was similar across treatment sites, with additional research needed for squamous cell carcinoma.

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Retrospective cohort analysis examines nCRT's effects on pCR and ypN0 rates in esophageal cancer, highlighting the role of high-volume centers.

Singh et al. (2025) studied this question.

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Retrospective cohort analysis examines nCRT's effects on pCR and ypN0 rates in esophageal cancer, highlighting the role of high-volume centers.