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September 27, 2025Frontiers in ImmunologyOpen Access

The microbiota-gut-brain axis in depression: unraveling the relationships and therapeutic opportunities

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The microbiota-gut-brain axis significantly influences depression development and management.
Alterations in gut microbiota are linked to neuroendocrine and neuroimmune disruptions associated with depression.
Advanced therapeutic methods targeting the microbiota offer new opportunities for depression treatment.
Challenges remain in understanding the mechanisms and ensuring efficacy and safety of microbiome interventions.

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This review discusses microbiota-gut-brain axis involvement in depression, highlighting therapeutic strategies like probiotics.

Zhu et al. (2025) studied this question.

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