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To explore effective treatments targeting the microbiota-gut-brain axis for managing depression.

Microbiota-Gut-Brain Axis in Major Depression: Pathophysiology and Psychobiotic Interventions

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To explore effective treatments targeting the microbiota-gut-brain axis for managing depression.
Literature review conducted using the PubMed database
Keywords included microbiota-gut-brain axis, psychobiotics, and various gut health terms
Evidence gathered varies across experimental designs and populations.
Modulation of gut microbiota can restore microbial balance and reduce neuroinflammation.
Psychobiotics, prebiotics, and high-fiber diets can improve mood and behavior in depression-related contexts.
Need for standardized guidelines and large-scale trials was emphasized due to observed heterogeneity.

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Review reveals the importance of MGB axis modulation for managing depression through dietary and psychobiotic interventions.

Pietrzak et al. (2026) studied this question.

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