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September 27, 2025Open Access

Altered coding of environmental boundaries in human aging: an fMRI study

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Authors

VSVladislava SegenMSMatthias StanglJSJonathan P. Shine

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Overview

fMRI study reveals how aging alters spatial memory and neural representation of environmental boundaries.

Key Points

  • Aging significantly alters the use and neural representation of environmental boundary information.
  • Older adults demonstrated enhanced memory accuracy for objects near boundaries and more rigid navigation patterns.
  • Functional MRI reveals that older adults exhibit reduced neural activity in the entorhinal cortex with distance from boundaries.
  • Findings suggest that reliance on boundary cues may contribute to spatial memory decline with aging.

Cite This Study

Segen et al. (2025) studied this question.

synapsesocial.com/papers/68d7be6ceebfec0fc5238049https://doi.org/10.1101/2025.09.25.678564
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered Coding of Environmental Boundaries in Human Aging: An <scp>fMRI</scp> Study2025
  2. 2Age differences in spatial navigation stem from a preference for familiar routes rather than impaired landmark-dependent strategies.2025 · 6 citations
  3. 3Age differences in spatial memory are mitigated during naturalistic navigation2024 · 11 citations
  4. 4Age- and sex-related differences in landmark recall following a virtual spatial navigation task2025 · 1 citations
  5. 5Less spatial exploration is associated with poorer spatial memory in midlife adults2024 · 3 citations