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October 18, 2025HippocampusOpen Access

Altered Coding of Environmental Boundaries in Human Aging: An fMRI Study

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Authors

VSVladislava SegenGerman Center for Neurodegenerative DiseasesMSMatthias StanglBoston Medical CenterJSJonathan ShineNational Institute of Technology Tiruchirappalli

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Implication

fMRI study reveals altered boundary information encoding in older adults, suggesting changes in spatial memory representation.

Key Points

  • Aging alters the neural representation of boundary information, specifically in the entorhinal cortex and subiculum.
  • Older adults showed a stronger boundary bias and less flexibility in navigation compared to younger adults.
  • Behaviorally, older adults performed better when objects were near boundaries, despite a decline in spatial precision.
  • Neural activity associated with boundary distance decreased in older adults, indicating maladaptive reliance on proximity cues.

Cite This Study

Segen et al. (2025) studied this question.

synapsesocial.com/papers/68f3eb011cfc5ad53f290691https://doi.org/10.1002/hipo.70044
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered coding of environmental boundaries in human aging: an fMRI study2025
  2. 2Age differences in spatial navigation stem from a preference for familiar routes rather than impaired landmark-dependent strategies.2025 · 6 citations
  3. 3Age differences in spatial memory are mitigated during naturalistic navigation2024 · 25 citations
  4. 4Age- and sex-related differences in landmark recall following a virtual spatial navigation task2025 · 2 citations
  5. 5Less spatial exploration is associated with poorer spatial memory in midlife adults2024 · 8 citations