Radiologic isolated syndrome in the early postpartum period (case report)

The terms radiologic isolated syndrome (RIS) and clinically isolated syndrome (CIS) are currently used in practical healthcare. RIS are foci in the white matter of the brain detected on MRI, which are oſten interpreted as a demyelinating process and suggest the presence of multiple sclerosis (MS) in patients. These changes do not have clinical manifestations and neurologic symptoms characteristic of MS. Multiple sclerosis (MS) is a chronic progressive disease of the central nervous system. MS is widespread among women of reproductive age, which poses a challenge to both obstetricians and neurologists in terms of addressing the planning and management of pregnancy and childbirth. Therefore, the clinical and prognostic significance of these changes in patients with RIS remains controversial. But it is undeniable that patients with RIS are at high risk of developing MS: about 2/3 of patients have progression according to MRI and about 1/3 of patients have clinical symptoms within 5 years of follow-up. In the case that we would like to present to you, a separate clinical episode developed against the background of RIS, manifested by a seizure syndrome in the postpartum (aſter cesarean section) period, which suggested that this was the debut of CIP against the background of an existing but undetected RIS. This prompted us to describe this case and present it to researchers and practicing physicians.