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September 27, 2025JCEM Case ReportsOpen Access

Adult Hypophosphatasia in a Middle-Aged Patient With Recurrent Fractures: Prevention of New Fractures With Asfotase Alfa

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Authors

DIDaisuke InoueKIKota IshizawaYTYusaku Takamura

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Overview

Case report shows reduced fractures and improved motor function in adult hypophosphatasia with asfotase alfa, suggesting potential benefits for similar patients.

Key Points

  • Treatment with asfotase alfa resulted in no new fragility fractures for the patient, marking a significant improvement.
  • The patient showed improvements in motor function and fewer falls after 12 months of enzyme replacement therapy.
  • Diagnosis of hypophosphatasia often gets delayed, but low serum alkaline phosphatase levels and genetic testing can confirm it.
  • Chronic pain persisted despite the positive changes in other health aspects, indicating treatment may not address all symptoms.

Cite This Study

Inoue et al. (2025) studied this question.

synapsesocial.com/papers/68d7be6ceebfec0fc52381d9https://doi.org/10.1210/jcemcr/luaf210
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Experiences with the use of asfotase alfa in three patients with childhood-onset hypophosphatasia2026
  2. 27336 Decades In The Dark: The Long Road To Diagnosing And Treating Hypophosphatasia2024
  3. 3A Rare Case Presentation of Hypophosphatasia: Bone Pain and Mild Fatigue in a 79-Year-Old Male2025
  4. 4Lifetime follow-up of an adult patient with pediatric-onset hypophosphatasia complicated with advanced chronic kidney disease2025 · 2 citations
  5. 57655 Genetic Mysteries Unveiled: Unusual Mutation Unraveled In Hypophosphatasia2024