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September 27, 2025PathogensOpen Access

How Does Porcine Epidemic Diarrhea Virus Escape Host Innate Immunity?

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Authors

JLJinyuan LiHLHao LuGHGaowei Hu

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Overview

This review summarizes the mechanisms PEDV uses to evade innate immunity, indicating crucial insights for control strategies.

Key Points

  • PEDV significantly threatens neonatal piglets, leading to high lethality and economic losses in the swine industry.
  • The review outlines how PEDV alters host intracellular signaling pathways to bypass innate immune defenses.
  • PEDV antagonizes antiviral factors and immune genes, thereby suppressing the host’s innate immune response.
  • Understanding PEDV's evasion strategies is essential for developing effective therapeutic interventions.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d7be70eebfec0fc5238404https://doi.org/10.3390/pathogens14100971
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Also Consider

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  1. 1Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus2026
  2. 2[Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus].2025
  3. 3PEDV Structural Proteins with Emphasis on M Protein as an Immunomodulatory Factor in Porcine Innate Immunity2025
  4. 4Integrated Metabolomic and Transcriptomic Analysis Reveals Host Response Mechanisms to Porcine Epidemic Diarrhea Virus Infection in Pigs2026
  5. 5Mechanism by which porcine transmissible gastroenteritis virus disrupts host innate immunity2025