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April 10, 2026Veterinary SciencesOpen Access

Integrated Metabolomic and Transcriptomic Analysis Reveals Host Response Mechanisms to Porcine Epidemic Diarrhea Virus Infection in Pigs

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Authors

YZYang ZhouTLTongxi LuJWJie Wang

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Overview

Integrated analyses uncover host response mechanisms to PEDV infection in pigs, suggesting targets for antiviral strategies.

Key Points

  • This research aims to identify the host response mechanisms involved in porcine epidemic diarrhea virus (PEDV) infection in pigs.
  • Conducted transcriptomic analysis on PEDV-infected Large White pigs
  • Performed metabolomic analysis to identify differential metabolites
  • Analyzed data for differentially expressed genes and metabolites
  • Investigated the impact of specific metabolites on PEDV infection and inflammation
  • Identified 692 differentially expressed genes related to PEDV infection
  • Found 1485 differential metabolites, including significant pathways
  • Detected key metabolites like Dehydroepiandrosterone (DHEA) that inhibit PEDV and reduce inflammation
  • Revealed co-enrichment of genes and metabolites in steroid hormone biosynthesis and bile secretion

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69d894326c1944d70ce05279https://doi.org/10.3390/vetsci13040313
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic reprogramming in the enterocytes of neonatal piglets infected with porcine epidemic diarrhea virus: integrated omics and multi-batch analysis highlight alterations in lipid metabolism and potential therapeutic targets.2026
  2. 2Comprehensive transcriptomic and metabolomic analysis of porcine intestinal epithelial cells after PDCoV infection2024 · 6 citations
  3. 3Impact of PEDV infection on the biological characteristics of porcine intestinal exosomes2024 · 2 citations
  4. 4Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus2026
  5. 5Spatially and temporally comparative proteomics provide insights into dynamic response patterns to PEDV infection2026