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May 2, 2026

Metabolic reprogramming in the enterocytes of neonatal piglets infected with porcine epidemic diarrhea virus: integrated omics and multi-batch analysis highlight alterations in lipid metabolism and potential therapeutic targets.

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Authors

MWMengjun WuQZQian ZhangXSXintao Shi

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Overview

Randomized trial demonstrates alterations in lipid metabolism in neonatal piglets infected with PEDV, suggesting therapeutic targets.

Key Points

  • The study aims to investigate metabolic changes in enterocytes of neonatal piglets infected with PEDV and to identify potential therapeutic targets.
  • Infected seven-day-old crossbred piglets (N=100) were enrolled from seven independent trials.
  • Analysis methods included transcriptomics, proteomics, and metabolomics of small intestine and blood samples.
  • Data from multiple batches were integrated for a comprehensive analysis of metabolic alterations.
  • PEDV infection significantly reprogrammed lipid metabolism in enterocytes.
  • Identified candidate hub genes included APOC3, CYP3A22, and ENPP7 related to lipid metabolism pathways.
  • Significant alterations were noted in retinol metabolism, mineral absorption, and amino acid metabolism following infection.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69f594e171405d493afffc6fhttps://doi.org/10.1128/spectrum.01625-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated Metabolomic and Transcriptomic Analysis Reveals Host Response Mechanisms to Porcine Epidemic Diarrhea Virus Infection in Pigs2026
  2. 2Impact of PEDV infection on the biological characteristics of porcine intestinal exosomes2024 · 2 citations
  3. 3Multi-omics profiling reveals that glycerol monooleate inhibits PEDV replication and attenuates intestinal injury of piglets by enhancing antioxidant capacity, modulating the TNF signaling pathway, and reshaping the intestinal microbiota2025
  4. 4Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus2026
  5. 5A tributyrin-monolaurin complex protects piglets against PEDV infection via viral inhibition, lipid metabolism restoration, and microbiota modulation2026