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This is a Literature Review study.

Neoadjuvant Stereotactic Radiotherapy for Brain Metastases

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Review highlights neoadjuvant stereotactic radiosurgery for brain metastases, suggesting potential benefits and challenges involved.

Neoadjuvant stereotactic radiosurgery shows comparable outcomes for local control and survival with postoperative radiation, indicating its effectiveness.
Preliminary studies suggest that this approach may lower the risk of leptomeningeal spread and radiation-related complications.
The technique’s ability to immobilize intact tumors improves imaging accuracy, which enhances radiation delivery while protecting healthy tissue.
Challenges such as lack of histopathological confirmation raise concerns about misdiagnosis, highlighting the need for further research.

Talapatra et al. (2025) studied this question.

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View Full Paper

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Authors

Review highlights neoadjuvant stereotactic radiosurgery for brain metastases, suggesting potential benefits and challenges involved.

Neoadjuvant stereotactic radiosurgery shows comparable outcomes for local control and survival with postoperative radiation, indicating its effectiveness.
Preliminary studies suggest that this approach may lower the risk of leptomeningeal spread and radiation-related complications.
The technique’s ability to immobilize intact tumors improves imaging accuracy, which enhances radiation delivery while protecting healthy tissue.
Challenges such as lack of histopathological confirmation raise concerns about misdiagnosis, highlighting the need for further research.

Talapatra et al. (2025) studied this question.

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