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July 30, 2025Discover OncologyOpen Access

Neoadjuvant stereotactic radiotherapy for brain metastasis: a review of ongoing clinical trials

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Authors

NANikan AmirkhaniESEhsan SaraeeMZMehdi Zeinalizadeh

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Overview

Systematic review analyzes 18 clinical trials investigating neoadjuvant radiotherapy for brain metastases, highlighting benefits and current trends.

Key Points

  • MAIN FINDING: Neoadjuvant stereotactic radiotherapy shows potential advantages over traditional postoperative methods.
  • KEY EVIDENCE: Review of 18 clinical trials examines local control and complications like radiation necrosis.
  • APPROACH: Systematic review of ClinicalTrials.gov to explore trial designs and endpoints for NaSRT.
  • SIGNIFICANCE: Research identifies gaps in current studies and points to the need for standardization in protocols.

Cite This Study

Amirkhani et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee01https://doi.org/10.1007/s12672-025-03290-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neoadjuvant stereotactic radiosurgery for brain metastases: Current evidence and clinical perspectives.2025 · 2 citations
  2. 2Neoadjuvant Stereotactic Radiotherapy for Brain Metastases2025 · 1 citations
  3. 3Neoadjuvant Stereotactic Radiosurgery for Brain Metastases: A Systematic Review and Meta-Analysis2025
  4. 4Neoadjuvant fractionated stereotactic radiotherapy followed by surgical resection for brain metastases: A multicenter, single arm phase II trial (NEO-TACTICS).2026
  5. 5PROTOCOL FOR A PROSPECTIVE, SINGLE-ARM, PHASE II CLINICAL TRIAL EVALUATING THE EffiCACY AND SAFETY OF NEO-ADJUVANT STEREOTACTIC RADIOSURGERY PRIOR TO SURGICAL RESECTION OF A DOMINANT BRAIN METASTASIS2025