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September 27, 2025

Elevated circulating tumor cells reflect high proliferation and genomic complexity in multiple myeloma.

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Authors

JGJuan‐José GarcésMemorial Sloan Kettering Cancer CenterBDBenjamin DiamondUniversity of MiamiTŠTereza ŠevčíkováUniversity of Ostrava

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Overview

Analysis shows high CTC levels reflect complex genomic features in multiple myeloma, indicating potential clinical implications.

Key Points

  • Higher circulating tumor cell levels are significantly linked to aggressive traits in multiple myeloma.
  • CTCs were evaluated in 540 NDMM patients, revealing correlations with complex genomic features.
  • Genomic and transcriptomic methods were used to study the implications of CTC burden on patient prognosis.
  • Integrating CTC data may enhance risk assessment and offer better clinical decision-making in multiple myeloma.

Cite This Study

Garcés et al. (2025) studied this question.

synapsesocial.com/papers/68d7cc66eebfec0fc52389aehttps://doi.org/10.1002/hem3.70218
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B03 | TRANSCRIPTOMIC PROFILING OF CIRCULATING TUMOR CELLS (CTCS) IN MULTIPLE MYELOMA REVEALS EGRESSION-ASSOCIATED PROFILE RELATED TO CTC BURDEN2026
  2. 2Biology of circulating tumor cells (CTCs) in multiple myeloma (MM): Comparative transcriptomic profiling reveals egression-associated changes related to CTC burden2025
  3. 3Low circulating tumor cell levels correlate with favorable outcomes and distinct biological features in multiple myeloma2024 · 12 citations
  4. 4Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights2026 · 1 citations
  5. 5Low circulating tumor cell levels correlate with favorable outcomes and distinct biological features in multiple myeloma2024 · 1 citations