What question did this study set out to answer?

This research aims to explore the transcriptomic differences between circulating tumor cells and plasma cells in multiple myeloma.

December 8, 2025Blood

Biology of circulating tumor cells (CTCs) in multiple myeloma (MM): Comparative transcriptomic profiling reveals egression-associated changes related to CTC burden

View Full Paper

Ask AI

Bookmark

Authors

Comparative gene expression analysis of CTCs and plasma cells points to mechanisms of egression in multiple myeloma.

This research aims to explore the transcriptomic differences between circulating tumor cells and plasma cells in multiple myeloma.
Analyzed PB samples from 29 NDMM patients using EuroFlow protocol and next-generation flow cytometry.
Paired CTCs and BM plasma cells were isolated using FACS and MACS techniques.
Conducted differential gene expression analysis with DESeq2 and assessed associations with survival outcomes.
Computed a CTC-like score weighted by gene expression values for assessing cytogenetic features.
Identified 1,142 differentially expressed genes between CTCs and BM plasma cells.
CTCs exhibited reduced expression of proliferation-related genes and increased CTC-like scores compared to BM plasma cells.
Higher CTC-like scores were associated with specific cytogenetic alterations, including 1q gain and t(14;16).

Radova et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

December 8, 2025Blood

View Full Paper

Ask AI

Bookmark

Authors

Comparative gene expression analysis of CTCs and plasma cells points to mechanisms of egression in multiple myeloma.

This research aims to explore the transcriptomic differences between circulating tumor cells and plasma cells in multiple myeloma.
Analyzed PB samples from 29 NDMM patients using EuroFlow protocol and next-generation flow cytometry.
Paired CTCs and BM plasma cells were isolated using FACS and MACS techniques.
Conducted differential gene expression analysis with DESeq2 and assessed associations with survival outcomes.
Computed a CTC-like score weighted by gene expression values for assessing cytogenetic features.
Identified 1,142 differentially expressed genes between CTCs and BM plasma cells.
CTCs exhibited reduced expression of proliferation-related genes and increased CTC-like scores compared to BM plasma cells.
Higher CTC-like scores were associated with specific cytogenetic alterations, including 1q gain and t(14;16).

Radova et al. (2025) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark