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September 27, 2025BMC ImmunologyOpen Access

Assessment of Cytokines TNF-alpha, IFN-gamma, TGF-beta-1, and IL-10 in Malaria Patients of the River Nile State , Sudan: A critical study of immune response

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Authors

MHMosab Nouraldein Mohammed HamadGAGhadeer M. AlbadraniAGAisha Ali M Ghazwani

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Overview

Analysis reveals cytokine levels impact immune response in malaria patients, highlighting TNF-alpha and IFN-gamma's roles.

Key Points

  • Cytokines TNF-alpha, IFN-gamma, and TGF-beta1 were significantly associated with parasite density.
  • Participants co-infected with COVID-19 showed lower uric acid levels, indicating immune modulation.
  • Higher levels of IL-10 were found in P. falciparum cases compared to P. vivax infections.
  • Study results suggest that cytokines play a critical role in the immune response to malaria.

Cite This Study

Hamad et al. (2025) studied this question.

synapsesocial.com/papers/68d7e84439bbb06045426c19https://doi.org/10.1186/s12865-025-00753-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interferon-γ and Interleukin-10 Profiles Correlate with Disease Severity in Sudanese Children with Plasmodium falciparum Malaria2026
  2. 2The Significance of TNF-α, CRP, and Hematological Parameters in the Prediction of Plasmodium Falciparum Parasitemia2024 · 1 citations
  3. 3Pro‐ and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study2024 · 3 citations
  4. 4Circulating Cytokine Profiles of Polyparasitized Individuals in Gabon.2020
  5. 5A Study on Cytokines In Severe and Non-severe Malaria in a Tertiary Care Hospital in Odisha.2024