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September 28, 2025PharmaceuticsOpen Access

Sustained-Release Oral Delivery of NSAIDs and Acetaminophen: Advances and Recent Formulation Strategies—A Systematic Review

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Authors

PDPaulina DrapińskaKSKatarzyna Skulmowska-PolokJCJoanna Chałupka

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Overview

Systematic review reveals enhanced formulation strategies for NSAIDs and acetaminophen, suggesting improved patient outcomes and compliance.

Key Points

  • Advances in sustained-release formulations significantly improve patient adherence and reduce dosing frequency.
  • The review included 64 studies, highlighting innovations in polymeric matrices, lipid-based carriers, and microspheres.
  • New manufacturing techniques like 3D printing and hot-melt extrusion enhance drug release profiles and stability.
  • Integration of in vitro performance with clinical safety outcomes remains a critical gap in the transition to practical applications.

Cite This Study

Drapińska et al. (2025) studied this question.

synapsesocial.com/papers/68d9051441e1c178a14f4a5dhttps://doi.org/10.3390/pharmaceutics17101264
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