Formulation and Evaluation of Oral Sustained Release Tablets

The present study focuses on the design, formulation, and evaluation of oral sustained release (SR) tablets to overcome the limitations of conventional immediate-release dosage forms. Frequent dosing associated with short half-life drugs often leads to poor patient compliance and fluctuating plasma concentrations, reducing therapeutic effectiveness. To address these challenges, sustained release systems are developed to deliver drugs at a predetermined rate for an extended duration, thereby maintaining steady plasma levels and improving clinical outcomes. In this investigation, SR tablets were prepared using hydrophilic and hydrophobic polymers through direct compression and wet granulation techniques. Results indicated that the optimized formulation exhibited controlled drug release over 12 hours, with release kinetics best fitting the Higuchi and Korsmeyer–Peppas models, suggesting diffusion and erosion-controlled mechanisms. Stability studies conducted under ICH guidelines confirmed the robustness of the optimized batch.. Future work should focus on in vivo studies and clinical trials to establish in vivo–in vitro correlation (IVIVC) and therapeutic relevance.