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May 1, 2026Open Access

Design Sustained Release Bi-Layer Tablet of Antihypertensive Drug for Improved Drug Delivery

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Authors

DSDr. P. M. Pimpalshende Shrinivas Rajesh Shinde*

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Overview

Randomized trial explores sustained release pills for better drug delivery in hypertensive treatment.

Key Points

  • This study aims to develop a sustained release bilayer tablet for antihypertensive drugs to improve drug delivery and patient compliance.
  • Developed formulations using different polymer concentrations to study their effect on drug release.
  • Evaluated precompression parameters including angle of repose and bulk density.
  • Designed the bilayer tablet to allow for immediate and maintenance dosing.
  • Demonstrated that bilayer tablets can effectively separate incompatible active pharmaceutical ingredients (APIs).
  • Showed improved stability and sustained release profiles compared to single-layer tablets.
  • Indicated enhanced patient compliance due to optimized therapeutic regimens.

Cite This Study

Dr. P. M. Pimpalshende Shrinivas Rajesh Shinde* (2026) studied this question.

synapsesocial.com/papers/69f4435b967e944ac5566a87https://doi.org/10.5281/zenodo.19875363
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