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When the high cardiac output exerts pressure on the arterial wall as blood flow increases, hypertension, or high blood pressure, occurs. Bi-layer tablets consists with one layer of the drug prepared for immediate release or a second layer intended for sustained release, these can be used as an sustained release method or as a second dose. A bi-layered tablet is used to break away two chemicals that are incompatible, release both drugs continually in combination, or create a sustained release tablet with an initial dose that is released immediately and a maintenance dose that is granted as with time. Bilayer tablets can be used for sustained release tablets, where the first layer is immediate release as the initial dose and the second layer is delayed release. It can also be used for the sequential release of two drugs combination or at separate two incompatible items.
Kothawade et al. (Thu,) studied this question.