This review explores bilayer tablets' design and technologies, enhancing drug release profiles for better patient outcomes.
Bilayer tablets are advanced oral solid dosage forms composed of two distinct layers, each formulated to achieve specific drug release profiles or to physically separate incompatible active pharmaceutical ingredients (APIs). These systems enable the combination of immediate-release (IR) and sustained-release (SR) components within a single unit, improving therapeutic efficacy, patient compliance, and pharmacokinetic control. This article reviews the principles, formulation strategies, manufacturing technologies, evaluation parameters, and recent advances in bilayer tablet systems, highlighting their growing importance in modern drug delivery.
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Abhishek Raj1* and Dr.Amit Sharma2 (2026) studied this question.
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