Pharmacological Profiling and Toxicity Assessment of Newly Synthesized Antihypertensive Lead Compounds

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Pharmacological profiling shows significant vasorelaxant activity in novel antihypertensive compounds, suggesting enhanced efficacy.

Several pyridazinone derivatives exhibited superior vasorelaxant potency compared to the reference hydralazine.
N-acylhydrazone compounds demonstrated moderate antihypertensive activity while also possessing analgesic effects.
Structure–activity relationship analysis identified key substituents that enhanced bioactivity in the new compounds.
Toxicity assessments showed most compounds had low hepatotoxic potential and were largely non-mutagenic.

Suvakanta Dash (2025) studied this question.

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Pharmacological profiling shows significant vasorelaxant activity in novel antihypertensive compounds, suggesting enhanced efficacy.

Several pyridazinone derivatives exhibited superior vasorelaxant potency compared to the reference hydralazine.
N-acylhydrazone compounds demonstrated moderate antihypertensive activity while also possessing analgesic effects.
Structure–activity relationship analysis identified key substituents that enhanced bioactivity in the new compounds.
Toxicity assessments showed most compounds had low hepatotoxic potential and were largely non-mutagenic.

Suvakanta Dash (2025) studied this question.

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