Clinical characteristics and outcome of acute leukemia in Down syndrome pediatric patients: a single centre experience in Egypt

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Retrospective study examines survival outcomes of acute leukemia in Down syndrome children, highlighting challenges.

Acute leukemia in Down syndrome patients indicates lower overall and event-free survival rates compared to non-Down patients.
Twenty-four out of 33 participants were diagnosed with acute lymphoblastic leukemia, with overall survival rates of 33.3%.
Notable poor prognosis was associated with initial white blood cell counts equal to or exceeding 50,000/mm3 in the ALL group.
This study emphasizes urgent improvements in supportive care for pediatric Down syndrome patients facing acute leukemia.

Ezzeldeen et al. (2025) studied this question.

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