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April 14, 2021Pediatric Hematology/Oncology and ImmunopathologyOpen Access

Acute lymphoblastic leukemia in children with Down syndrome: “Moscow–Berlin” experience

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Authors

РСР. Н. СупрунYRYu. V. RoumiantsevaОБО. И. Быданов

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Overview

Randomized trial analyzes inferior outcomes of treating Down syndrome acute lymphoblastic leukemia, suggesting new strategies for improved care.

Key Points

  • This study aims to analyze treatment outcomes for acute lymphoblastic leukemia in children with Down syndrome using the Moscow–Berlin protocol.
  • Analyzed primary ALL patients aged 1 to 18 receiving therapy in Russian and Belarusian clinics from January 2008 to December 2020.
  • Compared 135 DS-ALL patients to a matched-pair group from a database of 8296 ALL patients.
  • Measured event-free survival, overall survival, and treatment-related mortality rates.
  • Event-free survival for DS-ALL patients was 61 ± 6%, significantly lower than 84 ± 3% in the non-DS group (p<0.001).
  • Overall survival for DS-ALL patients was 74 ± 4%, lower than 89 ± 3% in the comparison group (p<0.001).
  • Treatment-related mortality in the DS-ALL group was significantly higher at 19.3 ± 3.5% compared to 3.9 ± 1.2% in the non-DS group (p<0.001).

Cite This Study

Супрун et al. (2021) studied this question.

synapsesocial.com/papers/6a219b494f27a676ef8b99cfhttps://doi.org/10.24287/1726-1708-2021-20-1-14-26
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