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July 28, 2025Expert Review of Hematology

Does down syndrome affect the prognosis of acute lymphoblastic leukemia? A systematic review and meta-analysis

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Authors

FMFrancisco Cézar Aquino de MoraesALArtur de Oliveira Macena LôboVSVitor Kendi Tsuchiya Sano

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Overview

Systematic review shows higher treatment-related mortality and induction failure in Down Syndrome patients with ALL, indicating serious implications for clinical management.

Key Points

  • The meta-analysis indicates Down Syndrome patients with Acute Lymphoblastic Leukemia have a higher risk of induction failure and treatment-related mortality.
  • A total of 63,054 patients from 16 studies were included, assessing the impact of Down Syndrome on outcomes in ALL.
  • Significant differences in outcomes like treatment-related mortality (RR 4.29) and induction failure (RR 5.51) were found for DS patients compared to those without DS.
  • The findings highlight the need for tailored treatment strategies for ALL patients with Down Syndrome to improve survival rates.

Cite This Study

Moraes et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cea58https://doi.org/10.1080/17474086.2025.2540401
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute lymphoblastic leukemia in children with Down syndrome: comparative analysis of treatment results according to ALL-MB 2008 and ALL-MB 2015 protocols2022 · 4 citations
  2. 2Acute lymphoblastic leukemia in children with Down syndrome: “Moscow–Berlin” experience2021 · 4 citations
  3. 3Clinical characteristics and outcome of acute leukemia in Down syndrome pediatric patients: a single centre experience in Egypt2025
  4. 4Transplantation outcomes in patients with Down syndrome‐associated acute lymphoblastic leukaemia: Implications for treatment intensity and the use of novel therapies2026
  5. 5The very rare association between T-cell acute lymphoblastic leukemia and down syndrome: a case report and review of the literature2026